What is Colosafe® ?

Colosafe® is an advanced DNA test you can do at home to screen for bowel cancer - privately, conveniently, and without a hospital visit.

Used by over 1 million people worldwide.
Colosafe® has been proven in international studies to find more cases of cancer early compared to standard stool tests, while giving fewer false alarms.

Colosafe®: A Highly Effective Screening Tool

Colosafe® offers excellent accuracy¹ in detecting colorectal cancer, especially in its early stages. This reliable test helps identify individuals who need further attention, making a real difference in patient outcomes.

Colosafe®

Sensitivity

Stage I - IV 84.22%

Stage I - II 86.71%

Specificity

97.85%

Total consistent rate

93.65%

Sensitivity is how often the test correctly finds cancer when it’s there, specificity shows how well it avoids false positives, and total consistency shows how often the result matches what colonoscopy later finds.

‍How Does Colosafe® Work?
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The Science Made Simple
Every day, cells from your colon naturally shed into your stool - this is completely normal. When cancer or polyps develop, these abnormal cells carry specific genetic changes that healthy cells don't have.
Colosafe® looks for one particular change: a genetic marker called SDC2 methylation.

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What is methylation? Think of it as a molecular "on/off switch" that controls whether genes work properly. It's a normal process in your body, but in cancer cells, the SDC2 gene becomes abnormally methylated - switched off when it should be working.

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Here's what makes this powerful: while tiny amounts of SDC2 methylation occur naturally in healthy cells, cancer cells show dramatically elevated levels. This stark difference makes detection possible.

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SDC2 – Your Early Alert System: This marker appears very early in bowel cancer development – often years before symptoms show up. As cancer cells naturally shed into your stool, they carry this methylation signature with them. It's like an early warning signal that cancer cells emit, allowing us to detect problems when they're most treatable.

Why Choose Colosafe?

Worried about colonoscopy?

Colosafe® can help determine if you really need one.

Still have symptoms after a negative standard test?

Advanced DNA technology can detect what standard tests may miss.

Not eligible for the national screening programme?

Detect and prevent cancer early - on your own terms.

Want peace of mind?

Clinically proven accuracy from home - reliable screening with Colosafe®.

For patients

Want to take a Colosafe test?

We are building a network of clinics, pharmacies, and healthcare providers across Ireland where you can order a Colosafe test. In the meantime, speak with your GP or specialist about Colosafe — they can order test kits directly.

Find a provider

Provider listings are being added county by county.

References

[1]Wang J., Liu S., Wang H., et al. Robust performance of a novel stool DNA test of methylated SDC2 for colorectal cancer detection: a multicenter clinical study. Clin Epigenetics. 2020;12(1):162.